AsseyMethod: Elisa RIA
Abbrevation: Gastrin
Sector: Biochemistry
SampleType: S
S.Vol: 0.3
Transport: 0.5 hrs. at 4-25c˚,at -20˚c,-70˚c
Storage: 4 hours at 4˚c ,30 days at -20˚c ,for longer tme at -70˚c
Test Name: Gastrin
Normal Range: Adult:up to 95 Children:up to 60
To detect an overproduction of gastrin, to help diagnose Zollinger-Ellison syndrome (ZE syndrome), to help diagnose multiple endocrine neoplasia type 1 (MEN-1) and to monitor for recurrence of a gastrin-producing tumour (gastrinoma)
When you have peptic ulcers and/or diarrhoea and abdominal pain that your doctor suspects is caused by excess gastrin; periodically to monitor for a gastrinoma recurrence
A blood sample taken from a vein in your arm.
You should fast for 12 hours and avoid alcohol for 24 hours before the test. Your doctor may also ask you to stop taking certain stomach medications for several days before the test.
This test measures the amount of gastrin in the blood. Gastrin is a hormone that regulates the production of acid in the stomach. It is produced by special cells called G-cells in the stomach during the digestive process. When food is eaten, the stomach becomes less acidic, promoting gastrin production. Gastrin in turn stimulates parietal cells to produce stomach acid. As acidity increases in the stomach, food is broken down and gastrin production falls. This feedback system normally results in low to moderate levels of gastrin in the blood. Rare conditions such as G-cell hyperplasia and Zollinger-Ellison (ZE) syndrome can cause an overproduction of gastrin and stomach acid. These conditions can lead to peptic ulcers that can be difficult to treat.
ZE syndrome is characterised by high gastrin levels, greatly increased stomach acid production, and by peptic ulcers due to gastrin-producing tumours called gastrinomas. Gastrinomas can form in the pancreas, the duodenum and rarely in other parts of the body. More than half of these tumours are malignant and can spread to other parts of the body, such as the liver. Even tiny tumours can produce large quantities of gastrin.
How is the sample collected for testing?
A blood sample is taken by inserting a needle into a vein in the arm.
Is any test preparation needed to ensure the quality of the sample?
You should fast for 12 hours and avoid alcohol for 24 hours prior to the test. Your doctor may also ask you to stop taking certain stomach medicines for several days before the test.