Sector: Hormone 2
Transport: at 2-8˚c, -20˚c
Storage: 1 week at 2-8˚c for longer time at -20˚
Test Name: Liver-Kidney-Microsomal
Normal Range: Negative:<20 Positive≥20
To help diagnose autoimmune hepatitis and distinguish it from other causes of liver injury
When you have hepatitis that your healthcare professional suspects may be due to an autoimmune-related process
A blood sample taken from a vein in your arm
Anti-Liver kidney microsomal type 1 (anti-LKM-1) antibodies are autoantibodies, proteins produced by the body's immune system that recognise and target its own enzyme called cytochrome P450 2D6 (CYP2D6), a protein found primarily in liver cells. The development of anti-LKM-1 antibodies is strongly associated with type 2 autoimmune hepatitis. This test detects the presence of anti-LKM-1 (or antibody against CYP2D6) in the blood.
Autoimmune hepatitis is an acute or chronic inflammation of the liver that can lead to liver cirrhosis and, in some cases, to liver failure. It is hepatitis that is not due to another identifiable cause, such as a viral infection, exposure to a drug or toxin, a hereditary disorder, or alcohol abuse. Anyone can develop the disorder, but the majority of those affected are women.
There are two main types of autoimmune hepatitis. Type 1 is the most common form of autoimmune hepatitis and is associated with the presence of smooth muscle antibodies (SMA) or anti-nuclear antibodies in the blood. Type 2 is less common and tends to be more severe. It is associated with anti-LKM-1 antibodies and primarily affects younger females.
How is the sample collected for testing?
A blood sample is obtained by inserting a needle into a vein in the arm.
Is any test preparation needed to ensure the quality of the sample?
No test preparation is needed.